Positive anti-nRNP/Sm antibody suggests that the patient may have systemic lupus erythematosus, mixed connective tissue disease, rheumatoid arthritis, etc. It is recommended to consult the doctor in time to find out the cause of the disease and then carry out drug treatment. Anti-nRNP antibody, i.e. anti-ribonucleoprotein antibody, belongs to antinuclear antibody and is commonly found in patients with mixed connective tissue disease, systemic lupus erythematosus and rheumatoid arthritis, while anti-Sm antibody is one of the specific antibodies of systemic lupus erythematosus, which suggests that patients may have systemic lupus erythematosus, and need to further improve the relevant examination and diagnosis, then carry out the appropriate drug treatment. Patients with positive anti-nRNP/Sm antibodies may also undergo further tests for rheumatoid factor, blood sedimentation, C-reactive protein, and other autoantibodies to confirm the diagnosis. Systemic lupus erythematosus, mixed connective tissue disease, rheumatoid arthritis and other diseases mainly rely on anti-rheumatic drugs such as cyclophosphamide, methotrexate, etc., glucocorticosteroids such as prednisone acetate tablets, etc., and non-steroidal anti-inflammatory drugs such as celecoxib, etc., for treatment. It is recommended that patients with positive anti-nRNP/Sm antibodies go to the Department of Rheumatology and Immunology of regular hospitals to find out the cause of the disease and follow the doctor’s instructions for treatment.