Which is the best material for skull repair surgery? Skull damage is a common accident. Patients with cranial bone damage for various reasons in life are eager to get good treatment to perfectly repair the damaged cranium. So, which cranial bone repair surgery is currently effective? In fact, with the progress of medical science, cranial bone repair is already a technically mature neurosurgery, as long as there is an experienced surgeon in charge, the success rate of surgery is not a problem, and there are very few cases of repair failure. At present, the key factor affecting the effect of cranial bone repair is the repair material. The traditional material for cranial repair is titanium mesh. The titanium mesh is shaped according to the skull defect by computer before surgery, and the shape and size of the titanium mesh are guided to be almost the same as the defective skull. Titanium mesh can meet medical requirements in terms of shape and hardness, but titanium mesh is a metal material, and its own characteristics have many restrictions on patients’ normal life, such as not being exposed to the sun for a long time, not being able to dye and perm hair, and not being able to engage in the original occupation for athletes engaged in strenuous sports. Not only that, but the postoperative hot and cold reaction of titanium mesh can lead to extreme sensitivity to environmental changes, as well as the possibility of various complications. Currently, a cranial prosthetic material called PEEK is gaining acceptance by physicians and patients alike. Compared to titanium mesh, PEEK offers more outstanding performance and clinical advantages, with virtually no postoperative complications. The high biocompatibility with human bone can perfectly compensate for the shortcomings of titanium mesh materials. Since the use of PEEK as a cranial repair material, clinical results have been remarkable, and patients have never had to undergo a second surgery. It can be said that PEEK is currently the best material for cranial bone repair.