High creatinine and normal urine routine may be caused by physiological reasons such as higher muscle content or eating more meat, or may be caused by acute kidney injury or chronic renal insufficiency. 1. Physiological reasons: some patients with elevated creatinine may be due to their own muscle content is high, or usually eat more meat, exercise more caused by routine urinalysis and ultrasound of the urinary system and other related examinations do not see any abnormality, after adjusting the lifestyle creatinine may return to normal. 2. Pathologic causes: (1) Acute kidney injury: pre-renal causes such as effective blood volume insufficiency, reduced cardiac output, etc., post-renal causes such as prostate hypertrophy, tumors, etc., there may be creatinine high urinary routine normal, and positive correction of reversible factors, such as rehydration and dilation, removal of obstruction, etc., creatinine can be gradually returned to normal. (2) Chronic renal insufficiency: such as hypertensive renal damage, gouty nephropathy may appear creatinine high urine routine normal. Actively control blood pressure, blood uric acid, can use drugs to reduce creatinine, such as medicinal charcoal tablets, Haikun Renxi and so on. If the patient found that the blood creatinine is elevated, it is recommended to go to the regular hospital in time, complete the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.