How to treat mixed thyroid nodules needs to be based on the nature of the nodule, to take targeted treatment, including conservative treatment, drug treatment, surgical treatment and other ways. 1. Conservative treatment: when the mixed nodules are benign and small, with no clinical symptoms and normal thyroid function, they can be left untreated, and only need to pay attention to adjusting the diet, regular thyroid ultrasound and thyroid function tests. 2. Drug treatment: when the mixed nodules are benign and accompanied by hyperthyroidism, there are symptoms of thyrotoxicity such as palpitations and anxiety, which can be treated with oral antithyroid drugs such as propylthiouracil; if accompanied by hypothyroidism, thyroid hormones such as levothyroxine sodium tablets can be supplemented. 3. Surgery: if benign mixed nodules gradually increase to localized bulging, compress the trachea or have obvious symptoms such as dyspnea and pain after eating, surgery such as radiofrequency ablation can be chosen to remove the lesion; or if the nodules are found to be malignant, they should be surgically removed. It is recommended that patients with mixed thyroid nodules go to regular hospitals in time to improve the relevant examinations, and standardize the diagnosis and treatment under the guidance of doctors to avoid delays.