Highly aggressive b-cell lymphoma, including diffuse large B-cell lymphoma, Burkitt lymphoma, etc. Regardless of the tumor stage of the patients, chemotherapy (CHOP regimen and R-CHOP regimen) is the mainstay of treatment, which can be supplemented by local radiotherapy. 1. CHOP regimen: including cyclophosphamide, doxorubicin, vincristine and prednisone, with every 2-3 weeks as one course of treatment, and two courses of consolidation treatment should be carried out after complete remission, and the total course of chemotherapy should not be less than six courses. 2. R-CHOP regimen: including rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone, i.e., rituximab is added before chemotherapy to get better therapeutic effect. 3. Adverse reactions such as hemorrhagic cystitis and infection may occur during the above chemotherapy, and it is contraindicated for those who are allergic to the drug components in the above chemotherapy regimen. Highly aggressive b-cell lymphoma needs to be correctly treated under the guidance of doctors, and different treatment plans should be formulated according to the patient’s own situation, do not use drugs by yourself.