The question of how long one can live with acromegaly cannot be answered with certainty and varies from person to person and is also related to treatment and care. Acromegaly is a progressive degeneration of motor nerve cells in the brain and spinal cord, manifested by progressive muscle weakness to the point of paralysis, as well as reduced speech, swallowing and respiratory function, until death by respiratory failure. Since the sensory nerves are not violated and do not affect the patient’s intelligence, memory or sensation, there is a clear relationship between the progression of the disease and symptomatic treatment and daily care. The average life expectancy from the onset of symptoms is between 2-5 years, with some patients surviving for periods ranging up to a dozen years. The prognosis of acromegaly is relatively poor, with epidemiological surveys showing that 50% of patients die within three years of onset, 20% survive for five years, and 10% survive for ten years, but patients with survival times >30 years are extremely rare.