Trypanosoma cruzi is an African human trypanosomiasis, also known as sleeping sickness, which is a vector-borne parasitic disease. Trypanosoma brucei and Trypanosoma brucei Rhodesia are the causative agents of African trypanosomiasis or African trypanosomiasis, and the vector insects are tsetse flies. Trypanosoma gambiae is found along rivers or along forests in West and Central Africa, while Trypanosoma rhodesiae is found in shrubs and thickets in the savannas and lakeshores of East Africa. Africantrypanosomiasis (Africansleepingsickness) has three clinical stages, the first of which is the invasion of the skin, causing varying degrees of hardness and nodules, which evolve into trypanosomatous chancre, which occurs in about one-third of patients and is often found on the exposed skin where the tsetsefly bites. The chancre occurs in about one-third of patients and is often found on the exposed skin where the tsetsefly bites and lasts for about 3 weeks. The second period is the hemolymph period, when symptoms such as periodic fever and parasitemia occur, including lethargy, swelling of lymph nodes in the back of the neck, joint pain, headache, and red rash on the trunk, and myocarditis, and jaundice due to hemolysis and liver damage. Once the brain is invaded, the disease will enter the third stage of meningoencephalitis, with headache, insomnia, movement disorders and behavioral disorders, and other symptoms including general weakness, dramatic loss of appetite and weight loss. The prevention of trypanosomiasis: 1. Spray insecticide on home environment and livestock in endemic areas. 2. 2. Avoid visiting areas with large numbers of tsetse flies; if travelers have to go, they should wear long sleeves and long pants to cover the exposed parts of their bodies and avoid wearing blue clothes that attract tsetse flies. 3. Install screens on windows and doors at home. 4.Use and sleep under mosquito nets. 5.Strengthen hygiene education to promote the importance of how to avoid vector mosquito bites. 6.Strengthen hand washing. 7, during the patient’s hospitalization, medical staff should adopt standard protective measures, hanging mosquito nets, touching blood, body fluids before and after the application of disinfectant hand washing. 8, clear the intermediate host tsetse fly habitat, such as riverside bushes. 9, good quarantine, find the source of infection to extinguish.