Heart disease generally develops to the late stage, indicating that the progress of the disease is more serious, mostly manifested as heart failure, at this time the physical symptoms of the patient will also become more and more serious, here we come to understand the late symptoms of heart disease. Advanced symptoms: chronic heart failure, advanced heart disease patients’ skin can be dark brown or dark purple, which is related to long-term hypoxia of body tissues, adrenocortical function decline, skin mucous membranes and limb bruises indicate extreme hypoxia of the heart. Late symptom 2: the patient’s hands and feet, the end of the fingers or toes are obviously thick, and the surface of the nail is raised like a drumstick, commonly found in chronic pulmonary heart disease or cyanosis type heart disease. Late symptom 3: Middle-aged and old people may have lower limb edema due to obstruction of venous blood return caused by cardiac insufficiency, upper body edema of the head and face can be seen, which may be accompanied by thoracic and abdominal fluid, jugular vein varicose and hepatomegaly, and often palpitation, shortness of breath, which can only be relieved by adopting a squatting position. Late symptom four: acute left heart failure caused by heart disease, respiratory obstruction can hemoptysis, pink or bright red foamy sputum, and even massive hemoptysis. Late symptom 5: mainly due to the sudden reduction of cardiac blood flow, brain tissue temporary ischemia caused by transient loss of consciousness, there will be a sudden fainting. Heart disease if the development of the late stage of the disease is very difficult to reverse, the earlier the discovery will be easier to treat, so patients with heart disease should be regularly checked on the body, for the degree of the disease is different relative to the treatment, in order to save the patient’s life.