Obese children are susceptible to pseudoacanthosis nigricans 13-year-old Xiaoming, grows tall, has a good appetite, special love of meat, sometimes a meal to eat several chicken legs, not good to move, grow fat. Recently, his mother noticed that Xiao Ming’s neck seemed to be always unwashed and black, like there was a layer of dust covering it. But no matter how much she washed it, it didn’t help, and it was getting darker and darker. Feeling that the situation was abnormal, his mother brought him to the hospital for a checkup. The doctor let Xiaoming undress to see, the results found that the child’s armpits, inner thighs obviously black, but also some thick, rough and uneven surface. The doctor told Xiaoming’s mother that Xiaoming was suffering from acanthosis nigricans, a disease that has many varieties, not only skin problems, but also indicates that the patient may be suffering from some kind of internal disease. Pseudoacanthosis nigricans, which is common in adolescents, is associated with metabolic diseases such as diabetes, hyperlipidemia or obesity, and many children with simple obesity are susceptible to this kind of skin disease. After examination, thankfully, Xiaoming only had high blood sugar and pseudoacanthosis nigricans. This disease is most common in adults between the ages of 25 and 60, but in recent years, the incidence of children and adolescents has increased significantly, mainly due to obesity, obesity with acanthosis nigricans patients with significantly higher plasma insulin levels than patients with simple obesity, that is to say, there may be a potential risk of diabetes and insulin resistance-related cardio-cerebral and cerebral vascular comorbidities, and therefore require a high degree of attention. The doctor told Xiaoming’s mother, must urge him to lose weight, more exercise, diet control, less meat, more vegetables and fruits, especially fiber-rich foods, otherwise it will be more and more powerful, but also cause really visceral problems. The skin lesions will subside after weight loss Acanthosis nigricans, also known as black keratosis or pigmented papillary dystrophy, is a rare skin disease characterized by warty thickening and deepening of pigmentation in places such as the neck, armpits and inguinal area, and can also occur in any part of the body. It is associated with genetics, tumors, endocrinology, and obesity. Also known as melanokeratosis, clinically divided into benign and malignant. Malignant acanthosis nigricans is mostly accompanied by adenocarcinoma of the digestive tract, with gastric cancer being the most common. Walton reported that gastric cancer could be up to 64% of the visceral tumors that can be accompanied by acanthosis nigricans, and Cross recalled that visceral tumors were accompanied by 247 cases of acanthosis nigricans, of which gastric cancer accounted for 112 cases. Acanthosis nigricans often appeared before the diagnosis of gastric cancer, which is an early clue to diagnose gastric cancer. This kind of dermatosis has certain characteristics, such as the skin is gradually light brownish brown, with papillae hypertrophy or papilloma, soft and gentle wart-like lesions with painful and itchy hyperpigmentation, hyperkeratosis in the folds of the skin, which often occurs symmetrically in the creases of the body, and the mucous membranes and the back of the hands and feet can also be involved, and it is progressively exacerbated with aggravation of the cancer, and sometimes, the skin changes subside after excision of the tumors. Sometimes the skin changes subside after excision, but reappear when the cancer recurs. Clinically, there are different types of acanthosis nigricans, which are mostly divided into four types in China: 1. Benign type: the disease starts to develop in childhood, and there is a family tendency, which may be related to the autosomal dominant inheritance of different phenotypic epitopes, and it is not possible to find out any reasons or triggers; however, the expansion of the skin lesions usually stops after puberty, and then they remain stable, or they decrease in severity. 2. 2. Malignant type: it develops in adulthood, often suggesting the presence of malignant tumors, most of which are gastric adenocarcinomas and so on. 3.Drug type: the rash may appear if niacin, adrenocorticotropic hormone, ethinyl estradiol and oral contraceptives are used. 4, pseudo-type: often occurs in obese patients, excessive sweating and local friction for this type of the main cause of the onset of a part of the endocrine disease may not be, a part of the prompt with Cushing syndrome, pituitary tumors, acromegaly, diabetes mellitus, Addison’s disease and so on. Either way, it may be related to endocrine disorders such as growth hormone. When such a rash is found, it is important to have a thorough examination in time, and to control diet and exercise to lose weight, and the lesions will subside after weight loss. It is recommended that obese patients with benign acanthosis nigricans must check their blood glucose and insulin function, observe whether there is diabetes and hyperinsulinemia, and promptly screen for internal diseases and tumors. If problems are detected, the rash will also reduce or slowly subside after prompt treatment. Otherwise, the neck and other body parts will become darker and darker, and the diagnosis and treatment of the disease will be delayed, missing the opportunity for early detection and treatment. Current medical research suggests that pseudo acanthosis nigricans occurs because the skin folds of obese patients sweat is not easy to dry, the skin is often in a wet state, the medical term for this situation is impregnated, coupled with repeated friction of the folds of the skin, leading to the thickening of the skin here, black, skin thickening to a certain degree to form a layer of black velvety skin damage, the medical term for this kind of skin damage for the velvet-like changes. The medical term for this skin damage is velvety change. For a longer period of time, a more prominent sarcoma will grow on this layer of black velvet, which is medically known as a dermatome. These skin lesions are most likely to occur in the neck, armpits, roots of the thighs, under the breasts in women, and other areas where the skin is folded. Pseudoacanthosis nigricans is common in adults aged 25-60, but in recent years, the number of obese children in China has gradually increased, and pseudoacanthosis nigricans in children is also on the rise.