Epididymal stones are also known medically as seminal vesicle stones, and stones that occur within the seminal vesicles are called seminal vesicle stones. It is extremely rare clinically. Due to chronic inflammation of the seminal vesicles, ejaculatory duct obstruction, seminal vesicle fluid retention, metabolic disorders, etc. caused by inorganic salt crystals deposited on the shedding of epithelial cells and inflammatory exudate formation. Stones are often multiple, generally small, 1-2 millimeters in size, the surface is smooth and hard brown. Seminal vesicle stones can occur singly or in multiples, and rarely show symptoms, occasionally see blood sperm, ejaculation pain or perineal discomfort. Seminal vesicle stones are rare, round, hard and smooth. Corriere reported that the composition of seminal vesicle stones and pancreatic stones are very similar to the formation of pancreatic stones and secretion of pancreatic stone protein gene expression abnormalities, and thus the cause of seminal vesicle stone formation is considered to be the lack of protease in the semen. 1, often asymptomatic. There may also be pain in the groin, which may radiate to the testicles and perineum. Stones stay in the ejaculatory ducts, in the obstruction of semen discharge, can cause colic. Symptoms worsen when the penis is erected or when ejaculation occurs. There may be bloody semen. 2.Rectal palpation examination in the outer upper edge of the prostate can be touched more than one hard texture, surface smooth stone sense or have stone friction feeling. The seminal vesicles become hard and have pressure pain. 3, X-ray film can be found in the seminal vesicle area with stone shadow. Differential diagnosis of epididymal stones: 1, ureteral stones The colic caused by ureteral stones is often similar to the pain in the lower abdomen and groin caused by the obstruction of the ejaculatory ducts during the discharge process of seminal vesicle stones, which prevents the discharge of semen. But the pain has nothing to do with ejaculation, abdominal X-ray and urography in the ureteral pathway can be found opaque shadow. 2, seminal vesicle tuberculosis seminal vesicle tuberculosis calcified shadow and seminal vesicle stones in the X-ray film performance is similar. The seminal vesicle tuberculosis has a history of tuberculosis foci in the urinary tract and other parts of the body, and the lesion may ulcerate around the prostate and form a sinus tract in the perineum. The epididymis is often involved, enlarged and hardened with irregular nodules. The vas deferens shows beaded sclerotic changes. Mycobacterium tuberculosis can be found in prostatic seminal vesicle fluid or semen smear or Mycobacterium tuberculosis culture; typical tuberculous lesions can be seen in prostate biopsy. Asymptomatic seminal vesicle stones can be left untreated; if symptoms occur or obstruction worsens, symptomatic and anti-infective treatment may be indicated. There is no evidence that lithotripsy is effective. Seminal vesicle stones combined with prostatic hyperplasia, the diameter of 1,2mm or less, after prostatectomy to relieve the ejaculatory duct obstruction factors, there is a possibility of self-discharge. If the internal medicine treatment is not effective, and the symptoms are more serious and the person has already given birth, the only effective treatment is to remove the seminal vesicle together with the stone. For infertile patients with partial vasovaginal obstruction caused by seminal vesicle stones, since their testicular spermatogenesis is still normal, depending on the degree of inflammation, especially at the early stage of infection, the quality of semen can be improved through the application of antibiotics or a small amount of prednisone treatment to make the inflammation subside. If the obstruction of the vas deferens tract is more serious, urethroscopic longitudinal incision of the posterior urethra or resection of the seminal caruncle can be used, and the indigo carmine injected through the vas deferens is seen in the surgical field during the operation, which proves that the operation has been effected thoroughly, and the quality of spermatozoa improves in 45-60% of the patients after the operation, and the pregnancy rate reaches 29-35%, but attention should be paid to avoiding injury to the rectum and the urethra during the operation. Spermatozoa stones to the vas deferens obstruction caused by serious infertility, artificial insemination can be used. Some people also use the spermatophore made of silicone to plant under the skin, connect it to the epididymal duct, and then puncture the semen in the spermatophore for artificial insemination. Successful pregnancies have been reported, and the technique is constantly being improved.