Large fluctuations in blood pressure may be related to age, disease, medication, activity, etc. Excessive blood pressure fluctuations can aggravate endothelial damage, which can lead to cardiovascular disease, and can also lead to impaired kidney function. Blood pressure is a fluctuating process that is affected by factors such as drinking strong tea or coffee, strenuous exercise, and mood swings. Large fluctuations in blood pressure may be associated with age-related vascular sclerosis, diseases such as pheochromocytoma and primary aldosteronism, failure to take antihypertensive medication on a regular basis, and strenuous activity. High fluctuating blood pressure can also aggravate the damage to the endothelium of blood vessels, which may lead to coronary heart disease, stroke and other cardiovascular and cerebrovascular diseases. In addition to this, large fluctuations in blood pressure may also lead to an increase in proteinuria and a decrease in creatinine excretion, thus causing the patient’s kidney function to decline. Patients with high blood pressure must take antihypertensive drugs and monitor their blood pressure strictly according to the doctor’s instructions, and if there are large fluctuations in blood pressure, they should consult a doctor immediately. Further antihypertensive treatment under the guidance of professional doctors.