If a patient has significant pain in the heart with breathing, the following factors should be considered: first, consider high-risk chest pain conditions, such as acute myocardial infarction, acute coronary syndrome, pulmonary embolism, aortic coarctation, and tension pneumothorax, especially in the case of tension pneumothorax the heart will have clinical symptoms accompanied by severe pain with breathing. Secondly, moderate risk chest pain, such as patients with large pleural effusion and lung infection, will also have pain in the heart with breathing, and coronary artery disease with unstable angina will also have the above symptoms and manifestations. Then, for mildly dangerous chest pain, such as when a patient has intercostal neuralgia or herpes zoster, there will also be pain in the heart with breathing. Finally, trauma should not be ruled out, such as a rib fracture, which can cause significant pain in the heart with breathing.