Patients who wake up with ankle pain may be due to the presence of ankle injury, ankle inflammation, and ankle fatigue, as follows: First, ankle injury: Some patients may suffer from a minor ankle injury, which subsequently leads to such symptoms. If a patient has a mild sprain of the ankle joint before going to sleep, there are no obvious symptoms at that time, but with the accumulation of local inflammation, he or she may suddenly feel significant pain and swelling in the ankle joint after waking up. Second, inflammation of the ankle joint: Some patients have inflammation of the ankle joint, which subsequently leads to such symptoms, such as patients who have recently developed osteoarthritis of the ankle joint and have no obvious symptoms in normal times, but have a cold situation at night and will have obvious pain symptoms when they get up in the morning. Third, ankle fatigue: Some patients may suffer from excessive fatigue of the ankle joint, which may lead to such performance.