Patient: The patient is 52 years old, female. The onset of the disease was after the New Year, that is, back pain, wasting, and went to Harbin Medical University at the end of March. She had bone penetration 76% and chemotherapy for 21 days, but the effect was not very obvious, but worse, making both sides of the waist more painful and nerve pain. Now she is bedridden. I hope you can help me to reduce her pain and if there is a better way to treat myeloma, and I hope you can give us a good treatment plan. Thank you! Junling Zhuang: I don’t know what kind of chemotherapy protocol is used. Myeloma itself can destroy the bone and affect the nerves causing pain, and some chemotherapy drugs can also cause neuropathy. We need to see if there are any problems with the thoracic and lumbar vertebrae, and be careful of fractures when moving around. If the pain is severe, you need to apply painkillers.