Serpentine sores usually refer to herpes zoster, which is a contagious skin lesion caused by the reactivated varicella-zoster virus. Typical symptoms of herpes zoster are clustered blisters distributed in bands with pain. It can be treated with oral medications, topical medications, and physical therapy. Herpes zoster may be preceded by systemic symptoms such as malaise, fever, lack of appetite, and burning or searing pain in the affected skin. The skin lesions often first appear erythema, soon appeared grain to soybean papules, cluster distribution without fusion, followed by rapid change into blisters, blister wall tense shiny, blister liquid clarification. The lesions are arranged in bands along one of the peripheral nerves, mostly on one side of the body. Herpes zoster can be treated with oral antiviral drugs such as acyclovir and bromovudine, as well as topical medications such as glycerite lotion, acyclovir cream, and mupirocin ointment. Acute phase pain can choose non-steroidal anti-inflammatory drugs such as diclofenac sodium, ultraviolet light, spectrum therapeutic instrument, infrared radiation and other local irradiation, which can promote the blisters to dry up and crust, and relieve the pain. Once there are clusters of blisters with band-like distribution, you should consult a doctor in time and follow the doctor’s instructions to standardize the treatment, do not self-medication. At the same time, you should avoid scratching and touching the herpes, so as not to delay the condition.