Anti-Jo-1 antibody positivity is an autoantibody indicator of anti-Jo-1 antibody syndrome. For anti-Jo-1 antibody syndrome, patients often show interstitial pneumonia, joint swelling, as well as “mechanic’s hand” and Raynaud’s phenomenon, etc. Patients with anti-Jo-1 antibody positivity should be highly alert and go to the hospital rheumatology department for muscle enzyme spectrum The anti-Jo-1 antibody should be investigated by the rheumatology department. The treatment of anti-Jo-1 antibody syndrome is not completely curable, but mainly relies on glucocorticoids and immunosuppressive therapy, so patients with positive anti-Jo-1 antibodies must be diagnosed early and treated systematically, and most of the disease will be well controlled with regular medication, so don’t miss out on serious complications.