If a man has painful urethra after urination, it is recommended to go to the hospital for relevant examination to clarify the cause of the symptoms: First, if there is an acute urethritis causing painful symptoms, it is recommended to choose antibacterial agents for treatment according to the results of urine culture. For example, choose quinolone antibiotics or cephalosporin antibiotics, commonly used drugs include levofloxacin hydrochloride capsules, cefixime capsules, cefuroxime tablets and other drugs to carry out treatment. Secondly, if there are stones in the urethra or bladder, extracorporeal shock wave lithotripsy or lithotripsy and lithotripsy under urethroscopy or cystoscopy is recommended to relieve the patient’s pain. Thirdly, if there is a tumor in the bladder, then inpatient surgery is recommended. Minimally invasive surgery is performed to remove the tumor from the body so that no mucosal destruction occurs and the pain is relieved or disappears. Fourthly, if the pain is caused by contusion of the urethral mucosa after trauma, it is recommended to avoid spicy and stimulating diet, avoid holding urine for a long time, take oral pain medication such as diclofenac sodium capsule or fenpropathrin capsule to relieve the patient’s pain, and visit the hospital dynamically for observation and review.