Mosquito bites large swelling can be soapy water and other weak alkaline substances applied to the affected area to relieve itching, mild cases can be coated with glucocorticoid preparations as well as oral antihistamines, serious cases need oral glucocorticoids to relieve systemic symptoms. The more common mosquito bites are mites, mosquitoes, bedbugs, fleas, etc., need to pay attention to personal protection to avoid mosquito bites. 1. mosquito bite secretion of venom is acidic, irritation leads to skin redness, swelling, itching, can be coated with soapy water in the bite to neutralize the mosquito venom; mosquito bites may have burrs left in the wound, need to be repeated several times with adhesive tape, to remove the burrs, to relieve itching and pain. 2. Those with mild symptoms can apply glycerite lotion or glucocorticoid cream such as hydrocortisone cream, and take antihistamines such as loratadine orally to relieve itching and swelling. 3. If accompanied by fever, arthralgia, fatigue and other systemic symptoms, it is necessary to go to the hospital in a timely manner, if necessary, under the guidance of the doctor oral glucocorticosteroid treatment. If secondary bacterial infection, can be topical or oral antibiotics. Mosquito bites large swelling is recommended to go to the regular hospital treatment, so as not to delay the condition. Specific medication needs to follow the doctor’s instructions.