Spinal pain after the second dose of the New Crown vaccine may be related to the underlying disease and has little to do with the vaccine. The New Crown vaccine acts primarily on the body’s immune system. Theoretically, vaccination does not cause posterior spinal pain in vaccinated persons, and posterior spinal pain is not a definite adverse reaction to the vaccine. Therefore, if a vaccinated person develops posterior spine pain after completing the New Crown vaccination, it is mainly due to primary factors. Common diseases that may cause patients with posterior spine pain include trauma, spinal inflammation, lumbar disc herniation, cervical spondylosis, congenital dysplasia, pyelonephritis, angina pectoris, and bone tumors, etc. There are many related diseases, so it is necessary to comply with the guidance of the doctor’s prescription, combined with whether the patient has a recent history of trauma, and to carry out X-rays, blood test or even lumbar spine MRI related examination to find out the cause of the disease and then carry out symptomatic treatment. After vaccination, it is necessary to stay at the vaccination site for half an hour to help determine whether there is any adverse reaction. If symptoms are more pronounced, they need to be reported to the doctor and treated as soon as possible.