Calf and thigh soreness can be related to lumbar spine pathology, hip and knee pathology, excessive activity and trauma. Lumbar disc herniation, spinal stenosis and other compression of spinal nerve roots can cause soreness and pain, numbness and other symptoms in the thigh and calf. Severe causes muscle atrophy and muscle weakness. Hip and knee joint lesions, such as ischemic necrosis of the femoral head, osteoarthritis of the knee, etc., with a longer history of the disease will cause soreness and swelling of the thigh and calf, muscle weakness, muscle atrophy and other symptoms. Short-term activity is too large, thigh and calf muscle fatigue, resulting in excessive accumulation of lactic acid will cause soreness and pain and other symptoms. After the trauma caused thigh calf soft tissue damage, will also appear soreness and pain and other uncomfortable symptoms. If the symptoms of soreness and pain in the calf and thigh, it is recommended that the patient go to the hospital to improve the examination and receive regular treatment.