If a large blister of foot odor appears to break down; first, it is necessary to apply a local wet dressing of compound Phellodendron jelly eliminating rub or compound Phellodendron liquid coating, and also a wet dressing of furacilin solution or povidone iodine solution to prevent bacterial infection, and also to astringent effect on the wound. Secondly, fusidic acid cream or erythromycin ointment can be applied after the dressing to prevent bacterial infection and mixed with recombinant human bovine basic fibroblast growth factor gel to promote the recovery of the epidermis. Then, oral medication can be applied with Itraconazole capsules for antifungal treatment, along with the application of Phellodendron capsules or Gentian Liver Soft Capsules to enhance the effect of clearing heat and drying dampness.