Whether high cystatin C can be recovered depends mainly on the cause of its elevation. If acute kidney injury causes elevated cystatin C, it may recover with recovery of renal function after correction of reversible factors; if chronic renal insufficiency causes elevated cystatin C, it usually cannot recover. Serum cystatin C ranges from 0.6 to 2.5 mg/L in adults. Cystatin C in the original urine is almost completely taken up and broken down by epithelial cells in the proximal tubule and does not return to the bloodstream, and is only excreted in trace amounts in the urine. Therefore, serum cystatin C level is a sensitive and specific indicator reflecting glomerular filtration function. If cystatin C is elevated as a result of acute kidney injury, it may recover with the recovery of kidney function after correcting the reversible factors; or if some kidney diseases are detected at an early stage and receive timely and effective treatment, cystatin C may recover; if chronic renal insufficiency leads to elevated cystatin C, and the renal injury is irreversible, cystatin C is usually unrecoverable. If patients find high cystatin C, it is recommended to go to regular hospitals in time, complete the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.