Blisters on the heel of the foot should not be squeezed because if they are squeezed by themselves in a fungal environment, they may cause a corresponding secondary infection. Blisters on the heel of the foot may be caused by and for the following reasons: first, fungal infection caused by tinea pedis, which can be treated by applying terbinafine hydrochloride gel for application, and if the blisters are large, they can be extracted with a syringe under aseptic operation, and then fusidic acid can be applied after extraction to prevent infection. Secondly, blisters may be caused by friction, due to excessive walking or tight shoes, and can be left untreated if the blisters are small. If the blister is more than one centimeter in diameter, the wall of the blister is tense and full, and the patient feels pain, it is also possible to use the above treatment to extract the blister to relieve pressure and relieve pain.