Pins and needles on the lips can be seen in atopic dermatitis, lipitis, keratitis, etc., the treatment mainly includes general treatment, drug treatment, and need to be standardized under the guidance of a doctor. 1. Allergic dermatitis: mostly due to contact with allergens, such as cosmetics, medications, etc., causing acute and chronic inflammation of the mucous membrane of the lips leading to pins and needles. General treatment is mainly to avoid contact with allergic things in life, imported things need to be clean, pay attention to oral hygiene. Drug treatment is mainly to choose antihistamines such as loratadine, cetirizine. 2. Lipitis: can be manifested as dry lips, tingling, flaking, general treatment is mainly to change the habit of biting the lips, stop using suspicious food, drink water diligently. Medication is mainly gentamycin ophthalmic ointment and tretinoin cream for application. 3. Keratitis: when the scope is wider, it can cause numbness and tingling of the skin in the area of the corner of the mouth, which is mostly a fungal infection. In daily life, you need to pay attention to the hygiene around the mouth, keep a good mind, avoid anxiety. Drug treatment can be used for mycotoxin tablets, fluconazole and so on. Lips have pins and needles feeling should be timely to the hospital, so as not to delay the condition.