If the calves become sore after drinking, the following causes are common: First, vasodilation: drinking alcohol will cause the lower limbs, especially the calves, to become vasodilated, which will speed up the local metabolism and cause an increase in anaerobic metabolism within the calf muscles, resulting in the accumulation of acidic metabolites, leading to clinical symptoms of calf soreness. Second, produce a lot of acetic acid: after excessive drinking, alcohol will be metabolized into acetic acid in large quantities in the body, and acetic acid can enter the calf through blood circulation, stimulating the calf nerve and causing the clinical symptoms of calf pain. After drinking alcohol, the soreness of the calf is a normal phenomenon, and the clinical symptoms can be relieved quickly by drinking a lot of water and appropriate amount of massage and hot compress. Patients can also accelerate the metabolism of alcohol and relieve the clinical symptoms of calf soreness if they can do a moderate amount of aerobic exercise.