Physiologic jaundice in newborns subsides naturally in the order of the extremities, followed by the trunk, neck, and then the face, with the sclera of the eyes being the last to subside. If it is difficult to determine whether the jaundice of a newborn has subsided, you can go to the hospital to check the bilirubin level at 2~5 days. Physiologic jaundice in newborns appears in just the opposite order of fading, first appearing in the sclera, then moving from the head and neck to the trunk and then to the limbs. Physiologic jaundice is a temporary jaundice caused by the immature development of the liver’s capacity in newborns. In full-term infants, it usually appears two to three days after birth, peaks in four to five days, subsides in five to seven days, and does not last more than two weeks at the latest, and in premature infants, its duration can be delayed to three to four weeks at the latest. In this case, the newborn is generally in good condition, and the jaundice can subside on its own without special treatment. Pathologic jaundice, on the other hand, requires symptomatic treatment according to the cause and cannot subside naturally. If the newborn has any of the following conditions, it indicates that pathological jaundice may occur: ① newborn jaundice in the first 24 hours of life, or jaundice prolonged; ② jaundice subsided and then reappeared; ③ serum total bilirubin value rose more than 5mg / dl per day, or serum conjugated bilirubin is more than 2mg / dl. If any of the above conditions occurs in newborns, parents must be vigilant and seek medical attention as soon as possible for effective intervention and treatment under the guidance of specialized physicians.