Late stage liver cancer is inoperable and the survival time of patients is usually very short. Liver cancer is a kind of highly malignant tumor, which is insensitive to radiotherapy and chemotherapy, and surgery is the main treatment method. If patients with advanced liver cancer that cannot be operated also do not undergo any other anti-tumor treatment, and only focus on symptomatic supportive treatment, the survival time of patients will not be more than 6 months. Generally speaking, the natural course of liver cancer patients is just 3-6 months, but recently some new non-surgical therapies have emerged to prolong the survival time of inoperable patients. If patients are treated with targeted therapy, such as Sorafenib or Lenvatinib and other new drugs, and combined with immune checkpoint inhibitors, such as K and O drugs, which are hot at present, some of the effective patients can live more than one year or even longer, even if they are treated with only targeted therapy or immunotherapy, the effective patients will live one more year. In conclusion, even if advanced liver cancer is inoperable, adopting active treatment can prolong life, and with the development of medical science and the emergence of new drugs and methods, the survival period of patients with advanced liver cancer will be gradually extended.