Three years after the removal of the gallbladder, the liver function indexes of the patient are usually not abnormal. The removal of the gallbladder will not adversely affect the liver. Although the liver and gallbladder are adjacent to each other, the main function of the gallbladder is to store bile and the main function of the liver is to secrete bile, which is secreted by the liver for digestion and absorption. After removing the gallbladder, the bile secreted by the liver will continue to flow into the intestines, which can stimulate the intestines causing them to peristalsis too fast, leading to symptoms of diarrhea or indigestion. With the prolongation of time, the common bile duct expands and can store bile for compensation, so the patient’s physiological functions can gradually return to normal. Therefore, after cholecystectomy, especially after three years, it will not lead to abnormal liver function indexes. When liver function indexes are abnormal, it is firstly considered to be related to the damage of liver cells, and it is recommended to consult the gastroenterology department to find out the cause.