Case summary: The patient, male, 23 years old, had syncope with no obvious cause in June 2012, without incontinence, foaming at the mouth and twitching of the extremities, and ECG monitoring showed ventricular fibrillation, which was recovered after giving electric shock defibrillation. ICD was subsequently implanted and he recovered well after the operation. In February of this year, he had several episodes of ventricular fibrillation and recovered from ICD discharge. For further diagnosis, he came to our hospital and was admitted with an electrocardiogram, which revealed Brugada wave, and an ambulatory electrocardiogram, which showed typical Brugada syndrome-like changes in the ST segment (fornix and saddle type). Cardiac ultrasound: LVD: 38.7, RAS: 25.5, RVD: 14.7, EF: 60%; no abnormalities in intracardiac structures were observed. Cardiac CT: changes after pacemaker implantation, no clear abnormalities in cardiac structures. Combining the patient’s medical history and examination data, the patient’s diagnosis was basically clear: Brugada syndrome. In order to reduce or eliminate ventricular fibrillation episodes, the patient’s consent was obtained and the decision was made to perform radiofrequency ablation. Radiofrequency ablation: the left and right femoral veins were punctured, SR0, array balloon and safire med double curved large-tipped catheter were inserted to the right ventricular outflow tract and modeled, the RVOT low voltage region was marked, 50-55W/50℃ temperature-controlled discharge was performed, and the Brugada waveform in V1 and V2 leads of body surface ECG disappeared; the right femoral artery was punctured, the ablation catheter was delivered to the left ventricle, and the left anterior and left posterior P potential areas. Postoperative and follow-up : The Brugada waveform disappeared on the postoperative ECG, and the upward-sloping ST-segment elevation in leads V1 and V2 was seen at 0.2-0.4 mv, and no dynamic change of ST-segment was seen on the dynamic ECG. No episodes of ventricular fibrillation were seen at the follow-up for nearly 2 months, and the ST segment in leads V1 and V2 returned to normal on ECG. The patient had a recurrence of ventricular fibrillation and ventricular tachycardia six months after surgery. We gave pericardial puncture and epicardial re-ablation of RVOT low voltage area. No ICD discharge and no episodes of ventricular tachycardia and ventricular fibrillation were seen in the postoperative follow-up to date.