Low fever in advanced stage of kidney cancer needs to lower the body temperature first, which can be lowered by oral antipyretic drugs, such as ibuprofen, aspirin, etc., or by intramuscular injection of antipyretic drugs under the guidance of doctor, so as to avoid hyperthermia, and the cause of the disease needs to be found out, and the symptomatic treatment should be carried out under the guidance of doctor. If the low fever in advanced stage of kidney cancer is caused by inflammation and infection, anti-bacterial and anti-inflammatory drugs also need to be taken, which can be Roxithromycin, cefradine and other drugs under the guidance of doctor or clinical pharmacist. If the persistent low fever is caused by tumor, anti-tumor therapy and immunotherapy need to be strengthened, which can be combined with physical methods such as ice packs and cold compresses to lower the temperature. Patients with advanced kidney cancer should keep a good mindset, pay attention to nutritional supplementation, keep warm, maintain good sleep and improve the quality of survival.