There is no definite conclusion to the statement that “Si Reverse San can cure 27 kinds of diseases”. Si Reverse San has the efficacy of dispersing the liver and regulating qi (regulating the stagnation of the liver qi), regulating the qi, and treating the symptoms of stagnation of liver qi (liver qi does not flow smoothly) or yang yulin and syncope (yang qi does not flow smoothly, resulting in coldness of the limbs). Si Reverse San is composed of four medicines: Radix et Rhizoma Glycyrrhizae Praeparata, Citrus Aurantium Citri Reticulatae, Radix Bupleurum Chinense and Radix Paeoniae Alba. Si Reverse San can be used to treat the symptoms of Yang depression and syncope, such as lack of warmth in the hands and feet, slight body heat, abdominal pain, diarrhea, etc. It can also be used to treat the symptoms of Liver-Qi stagnation, such as distension and pain in the epigastrium and abdomen, irritability, and distension and stuffiness in the abdomen and ribs. The main treatment effect of the four reverse powder is more extensive, chronic liver and gallbladder diseases, gastrointestinal diseases, gynecological diseases, etc. Identification belongs to the yang depression and syncope or liver qi stagnation, can be used to identify the four reverse powder plus reduction of treatment, but this formula can treat 27 diseases is not accurate. Sihui San should be used correctly under the guidance of a professional physician, and it is forbidden to use this medicine for those who have a partial abundance of yin and yang.