Meige syndrome (Meige), also known as blepharospasm a mouthful of mandibular dystonia, is a limited dystonia disorder that manifests as bilateral eyelid spasms and involuntary facial dystonia-like movements. Clinical typing: Blepharospasm (BS): manifests as paroxysmal involuntary tightening-like spasmodic jerking or involuntary blinking of both eyelids. Blepharospasm combined with oromandibular dystonia (BS-OMD): In addition to blepharospasm, the muscles of the mouth, lips, and jaws also contract spastically, showing pouting, lip contraction, mouth opening, tongue extension, involuntary twitching of the corners of the mouth and facial muscles, and bizarre expressions. Oral and mandibular dystonia (OMD): only spasmodic twitching of the mouth, lips and jaw muscles. Treatment methods: mainly include oral medication, surgery, and local injection of botulinum toxin type A. 1, conservative medical treatment: oral drugs include: (1) dopamine receptor antagonists, such as haloperidol, Tebrile, inosine, etc.; (2) γ-aminobutyric acid drugs, such as Jiajing Valium, sodium valproate, etc.; (3) anticholinergic drugs, such as Antan, etc.; (4) tranquilizers, such as diazepam, clonazepam, etc.; (5) antidepressants, such as amitriptyline, alpren, etc. (2) Local injection of botulinum toxin type A: The effect of botulinum toxin type A can last for weeks to months, and the main complication is local muscle paralysis. The drug is injected into the eyelids, around the mouth and related parts of the face. About 30% of patients can have relief. 3. Stereotactic minimally invasive surgical treatment: Stereotactic microelectrodes can be chosen to guide the destruction of the inner brain nucleus pulposus (medial part of the pallidum) for surgical treatment, with an efficiency of 80%-90%. For patients with good economic condition, DeepBrainStimulation (DBS) can be chosen. The cost of hospitalization is $30,000-35,000. Hospitalization time is 7-10 days. 4.The latest joint program I: combination of nerve repair drugs efficient pathway treatment, can increase the efficacy, delay neurodegeneration aging, reduce disease recurrence. 5.The latest joint program II: combined cell transplantation-neural repair surgery, can increase the efficacy, delay aging and disease recurrence.
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