Patients with stage 4 colon cancer combined with liver metastasis usually have lost the chance of surgical resection and can be treated with chemotherapy, targeted therapy and radiotherapy. Stage 4 colon cancer combined with liver metastasis suggests that the patient is already in advanced stage, at this time, the chance of radical resection is usually lost, and comprehensive treatment is usually given: 1. Systemic chemotherapy: for patients with intravenous infusion of chemotherapeutic drugs, it is generally recommended to carry out systemic intravenous chemotherapy through PICC catheter, and for patients taking oral chemotherapeutic drugs, it is recommended to consider oral capecitabine tablets or oral Tegibeo chemotherapy. 2. Targeted therapy: through bevacizumab, cetuximab, regorafenib, furaquintinib and other targeted drugs, specifically targeting the malignant tumors in the body for treatment. 3. Radiotherapy:Preoperative radiotherapy can reduce the tumor and improve the resection rate. Postoperative radiotherapy can kill residual tumor cells. Radiotherapy alone is only used for advanced rectal cancer patients, which has the effect of stopping bleeding, analgesia and prolonging survival. 4. Interventional therapy: liver metastases can be treated by means of chemoembolization and radiofrequency ablation. It is recommended to go to regular hospitals for comprehensive assessment of the condition and follow the doctor’s instructions to cooperate with the treatment in order to improve the prognosis of the patients and prolong the survival time, so as to avoid delaying the condition.