Hand, foot and mouth disease is an acute infectious disease caused by enteroviruses (CoxA16, EV71), mostly occurring in preschool children, with the highest incidence in the under-3 age group. The main symptoms are maculopapular rash and herpes on the hands, feet and mouth, and in a few severe cases, meningitis, encephalitis, encephalomyelitis, pulmonary edema and circulatory disorders, mostly caused by EV71 infection, and the main cause of death is severe brainstem encephalitis and neurogenic pulmonary edema. Patients and latent infected persons are the source of infection, which is mainly transmitted through the gastrointestinal tract, respiratory tract and close contact. I. Presentation of common cases Acute onset, fever, scattered herpes on the oral mucosa, maculopapular rash and herpes on the hands, feet and buttocks, which may be surrounded by an inflammatory redness and less fluid in the herpes. It may be accompanied by cough, runny nose, and loss of appetite. Some cases present only with a rash or herpetic pharyngitis. The prognosis is good. A few cases (especially those younger than 3 years old) may develop meningitis, encephalitis, encephalomyelitis, pulmonary edema, circulatory disorders, etc. The condition is dangerous and can lead to death or sequelae. 1, neurological system: poor mental health, drowsiness, easily startled; headache, vomiting; limb myoclonus, nystagmus, ataxia, eye movement disorders; weakness or acute flaccid paralysis; convulsions. The meningeal stimulation signs and tendon reflexes are weak or absent; critical cases may show coma, cerebral edema, brain herniation. 2, respiratory system: shallow breathing, dyspnea or rhythm changes, lips and mouth cyanosis, oral vomiting white, pink or bloody foam (sputum); lungs can be heard in the wet nymphal woven 3, circulatory system: pale gray face, skin flowering, cold extremities, fingers (toes) cyanosis; cold sweat; increased or slowed heart rate, shallow pulse rate or weakened or even disappeared; increased or decreased blood pressure.