Hand, foot and mouth disease is an enteroviral disease, incubation period is generally 3-7 days, there is no obvious prodromal symptoms, most patients suddenly onset of disease. It mainly invades four parts of the body: hands, feet, mouth, and buttocks; clinically, it has the four characteristics of no pain, no itching, no crusting, and no scarring. Initially, mild episodic symptoms may be present. Due to painful oral ulcers, the child salivates and refuses to eat. Oral mucosal rash appears relatively early, initially as corn-like papules or blisters surrounded by a red halo, mainly on the tongue and both cheeks, and often on the side of the lips and teeth. The rash is not itchy, and the papules turn from red to dark in about 5 days and then fade; the herpes is round or oval and flat, with cloudy liquid inside, with a long diameter in line with the skin line, such as the size of a soybean, generally without pain and itchiness, and leaves no trace after healing. Hand, foot and mouth lesions may not all appear in the same patient. Blisters and rashes usually subside after a week. Complications “HFMD” manifests itself on the skin and mouth, but the virus can invade vital organs such as the heart, brain, and kidneys. In case of high fever and unexplained increase in white blood cells without detecting other foci of infection, be alert to the occurrence of fulminant myocarditis. In case of concomitant aseptic meningitis, the symptoms are fever, headache, stiff neck, vomiting, easy irritability and restless sleep; non-specific erythematous rash or even punctate hemorrhagic spots may occasionally be found on the body. Combined with central nervous system symptoms, it is more common in children up to 2 years of age. Epidemiological characteristics The disease is often prone to collective infection in childcare institutions. Cross-infection in the hospital can also cause transmission. The disease is highly contagious, with complex transmission routes, high epidemic intensity and rapid spread, and can cause a pandemic in a short period of time. “Hand, foot and mouth disease” regional distribution is extremely wide, Europe, America and Asia and other places do not have a strict regional, “hand, foot and mouth disease” can develop in all seasons, to summer, autumn is common, the onset of winter is less common. Although adults do not develop the disease, but may also become hidden infected, although no symptoms but contagious, but the reporter saw the situation in two hospitals in Fuyang, the parents of the children are not any protection, and does not have isolation conditions, which brings a certain amount of worry to the prevention and control of the epidemic.