Splenomegaly is also known as enlarged spleen, and the main cause of enlarged spleen is pain in the left upper abdomen, but there may be pain in other parts of the body, such as joint pain and pain in the liver area, and the parts of the body that cause pain may be different from each other. 1. Upper abdominal pain: hypersplenism causes enlargement of the spleen, which will stimulate the peritoneum of the spleen and involve the peritoneum, resulting in pain in the left upper abdomen. If the enlargement of the spleen is more serious and compresses the surrounding tissues and organs, the patient may have pain in the whole abdomen. 2. Joint pain: Leukemia, hemolytic anemia and other blood diseases often have symptoms of abnormally high white blood cells, which may lead to an enlarged spleen. A large number of white blood cells can also fill up the bone marrow and increase the pressure in the bone marrow cavity, therefore, patients with this kind of blood disease may also have bone and joint pain. 3. Liver pain: Liver diseases such as liver cancer and cirrhosis will cause portal hypertension, resulting in poor blood return to the spleen, which will lead to enlargement of the spleen. Besides left upper abdominal pain, these patients may also have pain in the liver area. If you find an enlarged spleen on examination, you should consult a doctor in time and follow the doctor’s instructions to standardize the treatment.