Small dose aspirin is one of the basic therapeutic drugs for hypertensive patients, to avoid possible adverse effects during long-term administration, patients should fully understand the possible problems and treatment methods in the application of aspirin, regulate its use, and give full play to its cardiovascular protective effect. 1, high dose application (5g/day) can inhibit thrombospondin formation and cause bleeding, aspirin should be used after blood pressure control is stable (<150/90mmHg). 2.Small dose aspirin means 75-325 mg per day, while the best dose of aspirin for hypertensive people is 75-150 mg per day. Aspirin should be used with caution if combined with gastric ulcer, severe liver disease or bleeding disorders. 3, the human body every day about 1/10 platelets are newly generated with function, the newly generated platelets with function can be suppressed to maintain more than 90% of the platelets do not play a role, aspirin can be taken once a day. 4, enteric aspirin takes 3-4 hours after taking to reach the peak of the blood drug, mild hypertension patients, bedtime aspirin has a mild antihypertensive effect, while the morning take no such effect. 5, non-enteric tablets aspirin is dissolved in the stomach, only for the first dose in the acute period or as an antipyretic and analgesic drug for short-term use, long-term use can choose enteric tablets. 6, long-term use of aspirin patients such as surgery, tooth extraction, bleeding or allergies, non-compliance with medical advice and other sudden discontinuation of the drug will induce new cardiovascular events in a short period of time, discontinuation should be very cautious. 7. Long-term aspirin users should have their platelets checked regularly, and should receive symptomatic treatment when they have gastrointestinal symptoms, and should be closely monitored to avoid gastrointestinal bleeding.