There is no such thing as the best hypoglycemic drug, only the most suitable drug for you, you should choose the drug according to your condition under the guidance of your doctor. The types of drugs commonly used in clinical practice include metformin, a-glucosidase inhibitors, sulfonylureas and insulin. 1. Metformin: It is suitable for patients with type 2 diabetes who have poor effect of diet and exercise treatment, and the commonly used drug is metformin. 2. α-glucosidase inhibitors: can reduce postprandial blood glucose, commonly used drugs are acarbose, voglibose. 3. Sulfonylureas: can promote insulin secretion, commonly used drugs are glimepiride and so on. 4. Insulin: It is suitable for type 1 diabetes and type 2 diabetes which is not well treated by oral drugs, such as Menthol 30 insulin. Antihyperglycemic drugs also include thiazolidinediones, glargine, DPP-4 inhibitors, etc. Diabetic patients need to use antihyperglycemic drugs under the guidance of clinicians.