Why do I need comprehensive treatment? The reason is the lack of effective therapies. Although a lot of research is being conducted, such as the development of new chemotherapy drugs, new methods of radiotherapy (conformal, respiratory gating), simultaneous radiotherapy, new drugs for targeted therapy, and biological therapy. But most of them are in the research and development stage. Therefore, combined therapy is the most effective method at present. There is a tumor in the chest, which is so big that it makes the chest stuffy and shortness of breath, and it is really painful to lie down and sleep; after chemotherapy, there is an effect, and the tumor shrinks, but what about the residual tumor? Radiotherapy makes the residual tumor shrink again, the mediastinum shape is finally restored, and the patient can dance and laugh. The patient’s mediastinal tumor was oval in shape, with a diameter of 15 cm, and the trachea was compressed and could not lie down. After chemotherapy, the tumor shrank significantly and the tracheal compression was reduced, but it was still 6 cm in diameter. After radiotherapy, the tumor shrank further and was given the opportunity to be surgically removed. The residual tumor was completely removed and the patient was cured. The above examples illustrate the remarkable efficacy of combined treatment. 1. NSCLC treatment: Comprehensive treatment approach for stage I non-small cell lung cancer: Treatment approach is based on clinical evaluation: history, physical examination, biochemistry, lung function, chest radiograph, CT monitoring. If it is feasible and does not add additional cost, it can be considered for clinical trials. (1) Patients who can be operated: mediastinal CT examination, and mediastinoscopy can also be considered for non-peripheral small T1, and if the diagnosis is > stage I take the appropriate treatment, other cases can be treated surgically. (2) For those with poor cardiopulmonary function or who do not accept surgery, radiotherapy of 5000~6500 cGY is indicated. Follow-up: History, physical examination, chest X-ray, and fibrinoscopy (if necessary) are reviewed annually, and every 3 months if abnormalities are found after surgery. Comprehensive approach for stage II non-small cell lung cancer: Based on clinical evaluation, history, physical examination, biochemistry, pulmonary function, chest radiograph, CT (chest, upper abdomen, and bone and brain) and fibrinoscopy (appropriate preoperative staging) to determine treatment approach. No additional cost and feasible to be considered for enrollment in clinical trials. (1) For those who can be operated, CT, or even consider mediastinoscopy, for a diagnosis of > stage II, treat accordingly, with other surgery or chemotherapy. (2) For those with poor cardiopulmonary function or who do not undergo surgery, radiotherapy or chemotherapy will be administered. Follow-up: Medical history, physical examination, chest radiograph, fibrinoscopy (if necessary) reviewed annually, and every 3 months if abnormal findings after surgery. IIIA Comprehensive approach to non-small cell lung cancer: Based on clinical evaluation, history, physical examination, biochemistry, pulmonary function, chest radiograph, CT (chest, upper abdomen, and bone and brain) and fibrinoscopy (appropriate preoperative staging) to determine treatment approach. No additional cost and feasible to be considered for enrollment in clinical trials.