The clinical manifestations of congenital chondrodysplasia mainly include deformity and dwarfism, as follows: First, deformity: the onset of fetal development will be accompanied by deformity, such as cleft lip and cleft palate, and some of the patients will die during the fetal period, puerperium or soon after delivery, and the surviving cases will gradually form a dwarf after 2-3 years of age, and a small number of patients will have the symptom of compression of the spinal cord or the cauda equina. Secondly, dwarfism: there are typical manifestations of dwarfism, patients will have a large head and short neck, forehead and occipital protrusion, jaw hypertrophy, nose root collapse, short and thick limbs, standing hands too wide, short and wide palms, short and thick fingers are long and separate from each other, the lower limbs are O-shaped legs, flat feet, waddling gait, and spinal development is relatively long, waist protrudes forward, buttock curls backward, and other manifestations. After timely treatment, the clinical symptoms can be improved to a certain extent, but it is usually difficult to be cured completely.