Can congenital syndactyly be inherited?

Congenital syndactyly is one of the more common hand deformities, with 10%-40% of patients having a family history of the disease, which manifests as autosomal dominant inheritance. Bilateral incidence can be up to 50%, and unilateral incidence is more common in the middle ring finger, followed by the ring little finger. The best time to operate for congenital syndactyly is around 18 months after birth. If the patient develops a bony deformity or if the deformity is further aggravated, surgery can be performed earlier. Because surgery can damage the blood supply to the hand or skin flap and cause necrosis of the fingers or skin, syndactyly usually requires staged surgical treatment. Patients usually complete all surgeries before school age.