The harm of uremia thrombocytopenia is greater, uremia patients will be due to coagulation dysfunction resulting in skin, gums, gastrointestinal tract and intracranial hemorrhage and other complications, if not intervened in a timely manner, it will exacerbate renal anemia, and in severe cases, it may also be fatal, so need to pay attention to it. Kidneys have the role of secreting a small amount of thrombopoietin, when in the uremic stage, the patient’s renal function is seriously impaired, thrombopoietin synthesis is reduced, resulting in thrombocytopenia; in addition, due to the body’s metabolic disorders, which will lead to the bone marrow hematopoietic function partially inhibited, leading to platelet function, resulting in coagulation disorders. Thrombocytopenia and platelet dysfunction may cause skin, gum, gastrointestinal tract and intracranial bleeding and other complications, because patients with uremia are often combined with renal anemia, long-term bleeding will lead to the patient’s anemia worsened, and in severe cases, it will be life-threatening, so the harm is greater. If there is a decrease in the number of platelets and dysfunction, the condition can be improved by transfusion of artificial thrombopoietin, platelets and other blood components if necessary. When thrombocytopenia is found in uremia, it is recommended to consult the doctor in time and follow the doctor’s instructions to standardize the diagnosis and treatment.