Common causes of ankle bone enlargement include hyperplasia, rheumatic immunity disease, trauma, osteochondrosis, bone tumor, etc. It is recommended to consult a doctor to find out the cause of the disease in time. 1. Hyperplasia and degeneration: mostly seen in the elderly, due to long time weight bearing walking or chronic strain, causing compensatory hyperplasia of ankle joints, manifested as larger ankle bones, pain when walking, and restricted activities. 2. Rheumatic immune disease: rheumatoid arthritis is common, which may lead to synovial hyperplasia of the ankle joint, and may also be manifested as enlarged ankle bones, and some of them may have redness, swelling and deformity. 3. Trauma: When the ankle is traumatized, it may cause bone or ligament damage, local swelling, pain and enlargement of ankle bones. 4. Osteoarthritis: related to the living environment and diet, it can be manifested as enlarged ankle bones, accompanied by elbow joints, wrist joints and finger joints, and so on. 5. Bone tumor: when there is a bone tumor in the ankle, due to the growth of the tumor, it may lead to bone destruction, and it can also appear that the ankle bone becomes bigger, and there may be pain, activity limitation and other manifestations. If the ankle bone becomes bigger, we should pay attention to it, and suggest to go to the regular hospital in time, give the corresponding examination, clarify the cause of the disease, and actively cooperate with the doctor for treatment.