Primary NS first of all, NS is actually nephrotic syndrome. There are three major types of nephrotic syndrome, primary nephrotic syndrome, secondary nephrotic syndrome, and the rare congenital nephrotic syndrome. Now the question is what is primary nephrotic syndrome all about? The main problem is that the basement membrane outside the glomerulus is abnormal, and the permeability of the basement membrane outside the glomerulus is increased. The protein in our blood, because of the increased permeability of the basement membrane, after the increased permeability of the basement membrane of the glomerulus, the protein in the blood, mainly albumin, leaks through the basement membrane into the urine, so when we check, there will be a large amount of protein in the urine. A person has two kidneys, each kidney is at least 1 million glomeruli, the two kidneys together should have 2 million glomeruli in our body, each glomerulus has a layer of basement membrane outside, the basement membrane it has a lesion, its permeability increases, the protein inside the blood will leak through the basement membrane to the urine inside, lost from the urine inside this way, come to the hospital to check will find that the urine This is the principle of the pathogenesis of primary nephrotic syndrome.