Mirtazapine and trazodone hydrochloride are both antidepressants, comprehensive safety and tolerability, mirtazapine is the 1st line of recommended drugs, trazodone is the 2nd line of recommended drugs, specific and the patient’s drug sensitivity, previous use of medication, etc., can not be generalized, and should be used in accordance with medical advice. 1. Mirtazapine It is a norepinephrine and specific 5-hydroxytryptophanergic antidepressant, common adverse effects include weight gain, drowsiness, etc. Very rarely, tremor, convulsive seizures, postural hypotension may occur. Precautions for use include prohibition of allergy to ingredients, caution in pregnant women, lactation is not advocated, infants and young children are not recommended to use, do not drink alcohol during the use of medication, should not drive a vehicle or work at heights and so on. 2. Trazodone Hydrochloride This product is 5-hydroxytryptamine and norepinephrine reuptake inhibitor antidepressant, common adverse reactions include drowsiness, occasional nervousness, dry mouth, headache, fatigue, dizziness, tremor, blurred vision, constipation, and a few upright hypotension, vomiting, tachycardia, nausea. Precautions for use include contraindication to severe cardiac arrhythmia, coma, severe hepatic impairment, children under 18 years of age, allergy to the ingredients, caution in pregnancy and lactation, and not to be combined with alcohol. Both of the above drugs are prescription drugs, the doctor will consider from various aspects to give medication, follow the doctor’s instructions can be used.