There are numerous diseases that cause dry cough without sputum, common ones are acute bronchitis, cough variant asthma, Mycoplasma pneumoniae pneumonia. The drug chosen needs to be decided according to the cause of the disease. 1. Acute bronchitis: mostly caused by viral infections, take symptomatic treatment as the main, often use dextromethorphan, pentoxifylline and other cough treatment; if combined with bacterial infections, according to the pathogen sensitivity test to select sensitive antibiotics, such as amoxicillin, cefaclor, and other anti-infective treatment. 2. Mycoplasma pneumonia: generally manifested as irritating dry cough, preferred macrolide antibiotics, such as azithromycin, roxithromycin, etc., can also choose quinolone antibacterial drugs, such as levofloxacin, moxifloxacin, etc.. 3. Cough variant asthma: a special type of bronchial asthma, often manifested as dry cough in the morning and at night, can be given inhalation budesonide, oral cotrimoxazole capsules and other treatments. There are many other diseases that cause dry cough, you need to improve the relevant laboratory tests in a timely manner, clear the cause of the targeted treatment, the above drugs are prescription drugs, need to use drugs under the guidance of a physician.