In recent years, there is an increasing trend of myeloma, which is insidious in origin and has atypical early symptoms, thus the best treatment opportunity is easily lost. Myeloma is a malignant plasma cell disease that often manifests clinically as anemia, pathological fractures, bone destruction and pain, as well as kidney lesions and immunoglobulin abnormalities. Because of the slow onset of this disease, patients can go for a considerable period of time without significant painful manifestations. Therefore, some patients will keep treating as rheumatism or lumbar vertebral osteophytes because of general joint pain; some will keep treating as simple anemia because of long-term nosebleeds and bleeding gums; some will mistake as general fractures after fractures occurring due to slight external force or improper exertion; some will treat as cirrhosis because of lower albumin and higher globulin (caused by the ratio of white globules); and some will treat as cirrhosis. There are those who consult nephrology because of positive urine protein and poor kidney function, etc., just can’t think of the point of multiple myeloma up. In fact, timely bone marrow aspiration is very important to diagnose myeloma, so that it can be detected early and treated early, and some patients can significantly prolong their survival through hematopoietic stem cell transplantation or application of targeted therapy.