Down’s screening low risk free beta (T)-HCG (Fβ-HCG) is high, need to do non-invasive tests or amniocentesis may be, the specific circumstances of the pregnant woman and the fetus need to be analyzed. Down’s syndrome screening is one of the routine tests during pregnancy, which is able to determine the risk factor of the fetus for congenital stupidity, neural tube defects, and so on. The test result shows that the Down’s syndrome low risk free beta (T)-HCG (Fβ-HCG) is high, which does not exclude the possibility of chromosomal abnormalities in the fetus. In this case, it is best to go to the hospital for further examination and choose amniocentesis or non-invasive DNA for detector test according to individual situation. It is recommended to keep a good mood during pregnancy, avoid too much tension and learn to regulate stress. If the examination finds abnormalities, the pregnancy should be terminated.