If you can’t make a fist with your hand, you need to exclude peripheral nerve factors, central nerve factors and orthopedic diseases. 1. Peripheral nerve factors: most of them are caused by nerve compression, such as nerve root cervical spondylosis, carpal tunnel syndrome caused by nerve compression, which will lead to numbness of the fingers and loss of muscle strength. 2. Central nervous system factors: most of them are caused by cerebrovascular accidents such as cerebral thrombosis or cerebral hemorrhage, or intracranial space occupation, etc., which leads to the decrease of muscle strength of one side of the limb and the weakening of grip strength. 3. Orthopedic diseases: rheumatoid arthritis, rheumatoid arthritis, gouty arthritis and other diseases, can also lead to weak fist. When there is a weakness in the handshake, you can consider the possibility of a variety of diseases, it is recommended to consult the hospital in a timely manner, under the guidance of the doctor for examination and treatment.