The possible clinical causes of pain on pressure in the ascending colon include ulcerative colitis, colon cancer and malignant lymphoma of the ascending colon. 1. Ulcerative colitis: this disease refers to a kind of chronic non-specific intestinal inflammatory disease, which is related to the environment, intestinal microorganisms, heredity and immunity, etc. Clinical manifestations include diarrhea, mucopurulent and bloody stools, and abdominal pain. 2. Colorectal cancer: Cancer cells of people suffering from this disease may invade the tissues of the ascending colon and cause pain when pressing the ascending colon, and some of the people suffering from this disease also have symptoms such as emaciation, weight loss and dyspnea. 3. Malignant lymphoma of the ascending colon: this disease belongs to malignant tumors of the lymphatic system, and its typical symptoms include pain in the ascending colon, night sweating, low-grade fever, emaciation, enlarged liver and spleen. If the symptoms persist, it is recommended to go to the hospital to improve the relevant examination for targeted treatment.